Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Galicia, Spain.
Psychophysiology and Neuroimaging Group, Institute of Biomedical Research Cadiz (INiBICA), Andalusia, Cadiz, Spain.
Neurobiol Aging. 2022 Sep;117:151-164. doi: 10.1016/j.neurobiolaging.2022.05.012. Epub 2022 May 28.
Cognitive Reserve (CR) is considered a protective factor during the aging process. However, although CR is a multifactorial construct, it has been operationalized in a unitary way (years of formal education or IQ). In the present study, a validated measure to categorize CR holistically (Cognitive Reserve Index Questionnaire) was used to evaluate the resting-state functional connectivity in 77 cognitively unimpaired participants aged 50 years and over with high and low CR, and matched brain global atrophy levels. The connectivity of networks linked to attentional (Dorsal Attention Network -DAN-) and executive (Frontal-Parietal Control Network -FPCN-) processes were evaluated by the combination of Independent Component Analysis and seed-based approaches, since these networks have been proposed as candidates to underlie the protective effect of CR in the aging context. Participants with high CR showed an increase of the connectivity in the FPCN and a decrease in the DAN with respect to the low CR group, correlating with neuropsychological scores and supporting that high CR is related to a better neurocognitive preservation during aging.
认知储备（CR）被认为是衰老过程中的保护因素。然而，尽管 CR 是一个多因素的结构，但它是以单一的方式（受教育年限或智商）来操作化的。在本研究中，使用了一种经过验证的整体分类 CR 的衡量标准（认知储备指数问卷）来评估 77 名认知正常、年龄在 50 岁及以上、CR 较高和较低、大脑整体萎缩程度相匹配的参与者的静息状态功能连接。通过独立成分分析和基于种子的方法相结合，评估了与注意力（背侧注意网络-DAN-）和执行功能（额顶控制网络-FPCN-）相关的网络的连接性，因为这些网络被提出作为 CR 在衰老背景下的保护作用的候选者。与低 CR 组相比，高 CR 组的 FPCN 连接性增加，DAN 连接性降低，与神经心理学评分相关，支持高 CR 与衰老过程中更好的神经认知保护有关。
