College of Food and Pharmaceutical Sciences, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Ningbo University, Ningbo 315800, China.
College of Food and Pharmaceutical Sciences, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Ningbo University, Ningbo 315800, China.
Food Res Int. 2022 Jul;157:111255. doi: 10.1016/j.foodres.2022.111255. Epub 2022 Apr 18.
The aim of this study was to explore the anti-obesity activity of thinned peach polyphenols (TPP) and their effects on gut microbiota. An obese mouse model was established using a high-fat diet, and high-throughput sequencing was used to analyze changes in gut microbiota in mice fed with TPP. The results showed that dietary TPP reduced body weight, promoted appetite, reduced liver injury, and reduced levels of TC, TG, LDL-C, ASL and ALT while increasing HDL-C. TPP also enhanced the richness and diversity of gut microbiota in later stages of feeding. Composition and correlation analysis indicated that TPP increased probiotics (such as Alistipes, Akkermansia, Klebsiella, Bacteroides) which negatively correlate with obesity. TPP also reduced the numbers of harmful bacteria (including Helicobacter, Anaeroplasma), which positively correlate with obesity. Probiotics and harmful bacteria cluster independently and the two groups affect each other negatively. These results suggest that TPP reduced obesity by affecting the composition of the gut microbiota in mice. TPP can therefore be used as an ingredient in food to prevent the development of obesity.
本研究旨在探讨稀化桃多酚（TPP）的抗肥胖活性及其对肠道微生物群的影响。采用高脂肪饮食建立肥胖小鼠模型，并用高通量测序分析 TPP 喂养小鼠肠道微生物群的变化。结果表明，饮食 TPP 可降低体重、促进食欲、减轻肝损伤，并降低 TC、TG、LDL-C、ASL 和 ALT 水平，同时升高 HDL-C。TPP 还增强了喂养后期肠道微生物群的丰富度和多样性。组成和相关分析表明，TPP 增加了与肥胖呈负相关的益生菌（如 Alistipes、Akkermansia、Klebsiella、Bacteroides）。TPP 还减少了与肥胖呈正相关的有害细菌（包括 Helicobacter、Anaeroplasma）的数量。益生菌和有害细菌聚类独立，两组相互负向影响。这些结果表明，TPP 通过影响肥胖小鼠肠道微生物群的组成来减轻肥胖。因此，TPP 可以用作食品的成分，以预防肥胖的发生。
