Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu, China.
Luzhou Laojiao Co. Ltd, Luzhou, Sichuan, China.
Food Res Int. 2022 Jul;157:111283. doi: 10.1016/j.foodres.2022.111283. Epub 2022 Apr 22.
An isolate of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus L7) with robust antioxidant capacity was screened from traditional fermented Xinjiang cheese. Here, we focused on evaluating the effect of L. bulgaricus fermented milk on acute alcoholic liver disease prevention using a mice model, with glutathione treated mice as positive control. The results showed that both fermented milk and glutathione feeding could relieve alcohol-induced oxidative stress and inflammatory responses significantly. However, fermented milk feeding seemed to hold more promise in restoring gut dysbiosis relative to glutathione. Enhanced abundance of potential pathogens, Porphyromonas sp. and Enterococcus sp., induced by alcohol was considerably attenuated by additional feeding of fermented milk. Different scenario was firstly observed when additionally fed with glutathione in this study, showing remarkably increased abundance of Bacteroides sp. and Enterococcus sp. Our results suggested the more robust capability of L. bulgaricus fermented milk in restoring alcohol-induced gut dysbiosis relative to glutathione, indicating its potential protective effects on alcohol-induced hepatic injury.
从传统发酵的新疆奶酪中筛选出具有较强抗氧化能力的德氏乳杆菌保加利亚亚种（L. bulgaricus L7）。在这里，我们专注于使用小鼠模型评估保加利亚乳杆菌发酵乳对急性酒精性肝病的预防作用，以谷胱甘肽处理的小鼠作为阳性对照。结果表明，发酵乳和谷胱甘肽喂养都能显著缓解酒精引起的氧化应激和炎症反应。然而，与谷胱甘肽相比，发酵乳喂养似乎更有希望恢复肠道菌群失调。酒精诱导的潜在病原体卟啉单胞菌属和肠球菌属丰度的增加，通过额外喂养发酵乳得到了显著抑制。在本研究中，当另外添加谷胱甘肽时，首先观察到不同的情况，显示出拟杆菌属和肠球菌属的丰度显著增加。我们的结果表明，与谷胱甘肽相比，保加利亚乳杆菌发酵乳在恢复酒精诱导的肠道菌群失调方面具有更强的能力，表明其对酒精性肝损伤具有潜在的保护作用。
