Capozzi Vito Andrea, Cianci Stefano, Scarpelli Elisa, Monfardini Luciano, Cianciolo Alessadra, Barresi Giuseppe, Ceccaroni Marcello, Sozzi Giulio, Mandato Vincenzo Dario, Uccella Stefano, Franchi Massimo, Chinatera Vito, Berretta Roberto
Department of Medicine and Surgery, University Hospital of Parma, I-43125 Parma, Italy.
Department of Gynecological Oncology and Minimally-Invasive Gynecological Surgery, Università Degli Studi di Messina, Policlinico G. Martino, I-98125 Messina, Italy.
Mol Clin Oncol. 2022 Jun 7;17(1):121. doi: 10.3892/mco.2022.2554. eCollection 2022 Jul.
Borderline ovarian tumors (BOT) represent 10-12% of ovarian cancer cases with a higher prevalence in young patients. Although reproductive outcomes are satisfactory after conservative treatment, several authors reported a higher relapse rate in patients undergoing fertility-sparing surgery compared with radical treatment. The aim of the present study was to identify predictive factors of BOT recurrence in patients with childbearing potential undergoing conservative treatment with unilateral salpingo-oophorectomy. From January 2010 to December 2020 all patients with childbearing potential undergoing conservative treatment for early-stage BOT were included in the analysis. Expert sonographers performed the ultrasounds and classified the ovarian lesion according to International Ovarian Tumor Analysis criteria. A total of 230 patients with BOT that underwent surgical treatment during the study period were analyzed. Of these, 82 patients met the inclusion criteria. Relapse was experienced in 11 cases (13.4%), one (1.2%) peritoneal surface and 10 (12.2%) recurrences on the contralateral ovary. Ovarian tumor size >50 mm (P=0.032; OR 7.317; 95% CI 0.89-60.29), multilocular cysts >10 loculi (P=0.016; OR 7.543; 95% CI 1.64-34.78), cysts with >4 papillae (P=0.025; OR 6.190; 95% CI 1.40-27.36) were statistically correlated with recurrent BOT. Overall, the present study showed that lesions with maximum diameter >50 mm (P=0.014), multilocular cysts >10 loculi (P=0.012) and cysts with >4 papillae (P=0.003) were independent predictive factors of BOT recurrence (P<0.001; correlation coefficient R=0.481) in patients with the potential to bear children undergoing conservative treatment.
交界性卵巢肿瘤（BOT）占卵巢癌病例的10%-12%，在年轻患者中患病率更高。尽管保守治疗后的生殖结局令人满意，但几位作者报告称，与根治性治疗相比，接受保留生育功能手术的患者复发率更高。本研究的目的是确定接受单侧输卵管卵巢切除术保守治疗的有生育潜力的BOT患者复发的预测因素。2010年1月至2020年12月，所有有生育潜力且接受早期BOT保守治疗的患者均纳入分析。专业超声检查人员进行超声检查，并根据国际卵巢肿瘤分析标准对卵巢病变进行分类。对研究期间接受手术治疗的230例BOT患者进行了分析。其中，82例患者符合纳入标准。11例（13.4%）出现复发，1例（1.2%）为腹膜表面复发，10例（12.2%）为对侧卵巢复发。卵巢肿瘤大小>50mm（P=0.032；OR 7.317；95%CI 0.89-60.29）、多房囊肿>10个房（P=0.016；OR 7.543；95%CI 1.64-34.78）、乳头>4个的囊肿（P=0.025；OR 6.190；95%CI 1.40-27.
