Internal Medicine Research Unit, University Hospital of Southern Denmark, Odense, Denmark.
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Basic Clin Pharmacol Toxicol. 2022 Nov;131(5):306-310. doi: 10.1111/bcpt.13768. Epub 2022 Jul 16.
In November 2013, the Kidney Disease: Improving Global Outcomes Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease was published, recommending statins for all individuals 50 years or older with an estimated glomerular filtration rate below 60 ml/min/1.73 m to lower the risk of major cardiovascular events. We quantified the prevalence of statin use among the target population before and after the guideline publication in a large Danish cohort of individuals with an estimated glomerular filtration rate below 60 ml/min/1.73 m , to investigate the effect of the guideline, but found no difference in the prevalence of statin use prior to and after the guideline publication.
2013 年 11 月，《改善全球肾脏病预后组织肾脏病临床实践指南：脂质管理》发表，建议所有年龄 50 岁及以上、估算肾小球滤过率（eGFR）低于 60ml/min/1.73m2 的患者使用他汀类药物，以降低主要心血管事件的风险。我们在一个 eGFR 低于 60ml/min/1.73m2 的大型丹麦队列中，对目标人群在指南发布前后使用他汀类药物的情况进行了量化，以调查该指南的效果，但在指南发布前后，他汀类药物的使用比例没有差异。
