Eli and Edythe Broad California Institute for Regenerative Medicine Center for Regenerative Medicine and Stem Cell Research, Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, United States.
Marine Biological Laboratory, Woods Hole, United States.
Elife. 2022 Jun 28;11:e78170. doi: 10.7554/eLife.78170.
Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.
虽然没有已知的活体脊椎动物拥有源自颌形成的下颌弓的鳃，但有人提出，颌是通过对祖先下颌鳃的改造而出现的。在这里，我们表明，调节眼睛血压的斑马鱼假鳃，是由下颌弓间充质和第一咽囊上皮发育而来的，并且与鳃具有相同的基因表达、增强子利用和发育依赖性。结合软骨鱼类的研究结果，我们在硬骨鱼类中的发现表明，在上颌脊椎动物的最后共同祖先中存在具有与鳃同源的下颌假鳃，这与脊椎动物颌的鳃起源一致。
