School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.
Nat Prod Rep. 2022 Sep 21;39(9):1766-1802. doi: 10.1039/d1np00077b.
Covering: June 2009 to 2021Natural products containing a phloroglucinol motif include simple and oligomeric phloroglucinols, polycyclic polyprenylated acylphloroglucinols, phloroglucinol-terpenes, xanthones, flavonoids, and coumarins. These compounds represent a major class of secondary metabolites which exhibit a wide range of biological activities such as antimicrobial, anti-inflammatory, antioxidant and hypoglycaemic properties. A number of these compounds have been authorized for therapeutic use or are currently being studied in clinical trials. Their structural diversity and utility in both traditional and conventional medicine have made them popular synthetic targets over the years. In this review, we compile and summarise the recent synthetic approaches to the natural products bearing a phloroglucinol motif. Focus has been given on ingenious strategies to functionalize the phloroglucinol moiety at multiple positions. The isolation and bioactivities of the compounds are also provided.
2009 年 6 月至 2021 年
含有间苯三酚基序的天然产物包括简单和寡聚间苯三酚、多环聚异戊烯基酰基间苯三酚、间苯三酚萜类、黄酮类、蒽醌类和香豆素类。这些化合物代表了一大类次生代谢产物，具有广泛的生物活性，如抗菌、抗炎、抗氧化和降血糖作用。其中一些化合物已被授权用于治疗用途，或正在临床试验中进行研究。多年来，它们的结构多样性和在传统医学和常规医学中的应用使它们成为热门的合成目标。在这篇综述中，我们总结了近年来具有间苯三酚基序的天然产物的合成方法。重点介绍了在多个位置官能化间苯三酚部分的巧妙策略。还提供了化合物的分离和生物活性。
