一种共构“拓扑”手性索烃。

Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.

J Am Chem Soc. 2022 Jul 13;144(27):11927-11932. doi: 10.1021/jacs.2c02029. Epub 2022 Jun 28.

Catenanes composed of two achiral rings that are oriented (C symmetry) because of the sequence of atoms they contain are referred to as topologically chiral. Here, we present the synthesis of a highly enantioenriched catenane containing a related but overlooked "co-conformationally 'topologically' chiral" stereogenic unit, which arises when a bilaterally symmetric C ring is desymmetrized by the position of an oriented macrocycle.

由两个手性环组成的轮烷，由于它们所包含的原子序列而呈现出取向（C 对称性），被称为拓扑手性。在这里，我们介绍了一种高度对映体富集的轮烷的合成，其中包含一个相关但被忽视的“共构 '拓扑' 手性”立体中心，当一个双侧对称的 C 环被取向的大环去对称化时，就会产生这种立体中心。