Department of Mechanical Engineering, University of Texas at Austin, Austin, Texas, USA.
Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin, Austin, Texas, USA.
Int J Numer Method Biomed Eng. 2022 Sep;38(9):e3635. doi: 10.1002/cnm.3635. Epub 2022 Jul 15.
Convection-enhanced delivery (CED) is an investigational method for delivering therapeutics directly to the brain for the treatment of glioblastoma. However, it has not become a common clinical therapy due to an inability of CED treatments to deliver therapeutics in a large enough tissue volume to fully saturate the target region. We have recently shown that the combination of controlled catheter movement and constant pressure infusions can be used to significantly increase volume dispersed (V ) in an agarose gel brain tissue phantom. In the present study, we develop a computational model to predict V achieved by various retraction rates with both constant pressure and constant flow rate infusions. An increase in V is achieved with any movement rate, but increase in V between successive movement rates drops off at rates above 0.3-0.35 mm/min. Finally, we found that infusions with retraction result in a more even distribution in concentration level compared to the stationary catheter, suggesting a potential increased ability for moving catheters to have a therapeutic impact regardless of the required therapeutic concentration level.
经颅超声药物透入（CED）是一种将治疗药物直接递送至大脑以治疗脑胶质瘤的实验性方法。然而，由于 CED 治疗方法无法将治疗药物输送到足够大的组织体积以完全饱和目标区域，因此尚未成为常规临床治疗方法。我们最近表明，控制导管运动和恒压输注的组合可用于显著增加琼脂糖凝胶脑组织模型中分散的体积（V）。在本研究中，我们开发了一种计算模型来预测各种回缩率下通过恒压和恒流速输注实现的 V。任何运动速度都可以增加 V，但在速度超过 0.3-0.35 毫米/分钟时，连续运动速度之间的 V 增加会逐渐减少。最后，我们发现与固定导管相比，回缩输注导致浓度水平分布更均匀，这表明移动导管具有治疗效果的能力可能增加，而与所需的治疗浓度水平无关。
