Elenes Egleide Y, Mehta Jason N, Hsu Fang-Chi, Whitlow Christopher T, Debinski Waldermar, Rossmeisl John, Tatter Stephen, Rylander Christopher G
Department of Biomedical Engineering, University of Texas at Austin, 301 E. Dean Keeton Street C2100, Austin, TX 78712-2100.
Department of Mechanical Engineering, University of Texas at Austin, 204 E. Dean Keeton Street, Stop C2200, Austin, TX 78712-1591.
J Eng Sci Med Diagn Ther. 2021 Feb 1;4(1):011003. doi: 10.1115/1.4048935. Epub 2020 Dec 2.
Standard treatment for glioblastoma is noncurative and only partially effective. Convection-enhanced delivery (CED) was developed as an alternative approach for effective loco-regional delivery of drugs via a small catheter inserted into the diseased brain. However, previous CED clinical trials revealed the need for improved catheters for controlled and satisfactory distribution of therapeutics. In this study, the arborizing catheter, consisting of six infusion ports, was compared to a reflux-preventing single-port catheter. Infusions of iohexol at a flow rate of 1 L/min/microneedle were performed, using the arborizing catheter on one hemisphere and a single-port catheter on the contralateral hemisphere of excised pig brains. The volume dispersed (V) of the contrast agent was quantified for each catheter. V for the arborizing catheter was significantly higher than for the single-port catheter, 2235.8 ± 569.7 mm and 382.2 ± 243.0 mm, respectively (n = 7). Minimal reflux was observed; however, high V values were achieved with the arborizing catheter. With simultaneous infusion using multiple ports of the arborizing catheter, high V was achieved at a low infusion rate. Thus, the arborizing catheter promises a highly desirable large volume of distribution of drugs delivered to the brain for the purpose of treating brain tumors.
胶质母细胞瘤的标准治疗方法无法治愈，且仅部分有效。对流增强递送（CED）作为一种替代方法被开发出来，通过插入患病大脑的小导管实现药物的有效局部递送。然而，先前的CED临床试验表明，需要改进导管，以实现治疗药物的可控且满意的分布。在本研究中，将由六个输注端口组成的分支导管与防止反流的单端口导管进行了比较。在切除的猪脑的一个半球上使用分支导管，在对侧半球上使用单端口导管，以1 L/分钟/微针的流速输注碘海醇。对每个导管的造影剂分散体积（V）进行了量化。分支导管的V值显著高于单端口导管，分别为2235.8 ± 569.7 mm和382.2 ± 243.0 mm（n = 7）。观察到最小程度的反流；然而，分支导管实现了高V值。通过使用分支导管的多个端口同时输注，在低输注速率下实现了高V值。因此，分支导管有望为治疗脑肿瘤将大量药物高度理想地递送至大脑。
