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经导管主动脉瓣植入术后早期出院的预测因素:来自 CoreValve 临床服务的见解。

Predictors of early discharge after transcatheter aortic valve implantation: insight from the CoreValve ClinicalService.

机构信息

Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa.

Cardiothoracic Department, Spedali Civili Brescia, Brescia.

出版信息

J Cardiovasc Med (Hagerstown). 2022 Jul 1;23(7):454-462. doi: 10.2459/JCM.0000000000001318.

DOI:10.2459/JCM.0000000000001318
PMID:35763766
Abstract

AIMS

The aim of this study was to minimize the procedure, and reduce the length of hospital stay (LoS) is the future objective for transcatheter aortic valve replacement (TAVI).Aims of the study are to identify procedural and electrocardiographical predictors of fast-track discharge in patients who underwent TAVI.

METHODS

Patients treated with TAVI included in the One Hospital ClinicalService project were categorized according to the LoS. 'Fast-Track' population, with a postprocedural LoS less than or equal to 3 days, was compared with the 'Slow-Track' population with a postprocedural LoS greater than 3 days.

RESULTS

One thousand five hundred and one patients were collected. Despite single baseline characteristics being almost similar between the two groups, Slow-Track group showed a higher surgical risk (P < 0.001). Patients in the Slow-Track group were more frequently treated with general anaesthesia (P = 0.002) and less frequently predilated (P < 0.001) and received a lower amount of contrast media. No difference between Slow-Track and Fast-Track patients was observed at 30 days in death and in cardiovascular rehospitalization.In the multivariable analysis, STS score of at least 4% [odds ratio (OR): 1.64; P = 0.01], general anaesthesia (OR: 2.80; P = 0.03), predilation (OR: 0.45; P < 001), NYHA 3-4 at baseline (OR: 1.65; P = 0.01), AVB I/LBBB/RBBB onset (OR: 2.41; P < 0.001) and in-hospital new PM (OR: 2.63; P < 0.001) were independently associated with a higher probability of Slow-Track.

CONCLUSION

Fast-Track patients were safely discharged home showing no difference in clinical outcomes after discharge up to 30 days compared with the Slow-Track group. The STS score, general anaesthesia, NYHA 3--4 at baseline, in-hospital onset of conduction disturbances and new PM implantation after TAVI turned out to be predictors of Slow-Track.

摘要

目的

本研究旨在减少经导管主动脉瓣置换术(TAVI)的手术程序和住院时间(LoS),这是未来的目标。本研究的目的是确定 TAVI 术后快速出院的程序和心电图预测因素。

方法

将参与 One Hospital ClinicalService 项目的 TAVI 治疗患者根据 LoS 进行分类。将术后 LoS 小于或等于 3 天的患者归入“快速通道”人群,与术后 LoS 大于 3 天的“缓慢通道”人群进行比较。

结果

共收集了 1510 名患者。尽管两组患者的基线特征几乎相似,但慢通道组的手术风险较高(P<0.001)。慢通道组患者更常接受全身麻醉(P=0.002),较少接受预扩张(P<0.001),接受的造影剂剂量也较少。在 30 天时,慢通道和快速通道患者的死亡率和心血管再入院率无差异。多变量分析显示,STS 评分至少为 4%[比值比(OR):1.64;P=0.01]、全身麻醉(OR:2.80;P=0.03)、预扩张(OR:0.45;P<0.001)、基线时 NYHA 3-4 级(OR:1.65;P=0.01)、AVB I/LBBB/RBBB 发作(OR:2.41;P<0.001)和住院期间新发起搏器(OR:2.63;P<0.001)与慢通道的发生概率更高独立相关。

结论

快速通道患者安全出院,与慢通道组相比,出院后 30 天内的临床结局无差异。STS 评分、全身麻醉、基线 NYHA 3-4 级、住院期间传导障碍和 TAVI 后新起搏器植入是导致慢通道的预测因素。

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