宋内志贺菌的高、低水平四环素抗性
High and low level tetracycline resistance in Shigella sonnei.
作者信息
Hawkins W A, Dale J W
出版信息
J Hyg (Lond). 1978 Aug;81(1):131-8. doi: 10.1017/s0022172400053833.
The results presented in this paper confirm the existence of two types of tetracycline resistance in Shigella sonnei. One group of strains had a high level of resistance to tetracycline and oxytetracyline, with a variable level of minocycline resistance. The second group had a lower level of tetracycline resistance and were sensitive to minocycline. After conjugation with E. coli K12 the selected E. coli transconjugants had the same levels of resistance as the parent Sh. sonnei strain, with one exception. Sh. sonnei 87 was resistant to a high level of tetracycline, but was able to transfer only low level resistance. It is suggested that Sh. sonnei 87 carriers two plasmids: pSU1, a conjugative plasmid conferring a low level of tetracycline resistance, and pSU2, a non-conjugative plasmid which confers a high level of resistance to tetracycline.
本文呈现的结果证实了宋内志贺菌中存在两种四环素抗性类型。一组菌株对四环素和土霉素具有高水平抗性，对米诺环素的抗性水平不一。第二组对四环素的抗性水平较低，且对米诺环素敏感。与大肠杆菌K12接合后，所选的大肠杆菌接合子具有与亲本宋内志贺菌菌株相同的抗性水平，但有一个例外。宋内志贺菌87对高水平的四环素具有抗性，但仅能转移低水平抗性。据推测，宋内志贺菌87携带两个质粒：pSU1，一个赋予低水平四环素抗性的接合性质粒；以及pSU2，一个赋予高水平四环素抗性的非接合性质粒。
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