School of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Prenat Diagn. 2022 Aug;42(9):1182-1189. doi: 10.1002/pd.6202. Epub 2022 Jul 2.
To explore the potential of circulating trophoblasts (TBs) as a non-invasive tool to assess placental health and predict obstetric complications.
We retrospectively reviewed maternal characteristics and pregnancy outcomes of 369 women who enrolled in our original cell-based NIPT (cbNIPT) study. The number of circulating TBs recovered from the maternal blood samples was recorded and expressed as fetal cell concentration (FCC). We evaluated if FCC can be used to predict pregnancy outcomes such as hypertensive disorders of pregnancy (HDP), fetal growth restriction, placental abruption, preterm labor, and pregnancy loss.
Receiver operating characteristic (ROC) analysis was performed to find the best cut off value to classify FCC into a low and high FCC group, and this cut-off point was calculated as 11.1 cells per 100 ml of blood. The adjusted odds ratio (aOR) for the composite morbidity was significantly increased for the high FCC group at an aOR of 1.6.
Circulating TB have the potential of predicting obstetrical complications such as HDP. Future studies, with larger sample sizes, should focus on the study of these cells as a biomarker for placental health and a possible screening or diagnostic tool for fetal genetic conditions.
探讨循环滋养层细胞（TBs）作为一种非侵入性工具评估胎盘健康和预测产科并发症的潜力。
我们回顾性分析了 369 名参加我们原始细胞为基础的无创性产前检测（cbNIPT）研究的女性的母体特征和妊娠结局。记录从母体血液样本中回收的循环 TBs 的数量，并表示为胎儿细胞浓度（FCC）。我们评估 FCC 是否可用于预测妊娠结局，如妊娠高血压疾病（HDP）、胎儿生长受限、胎盘早剥、早产和流产。
进行了受试者工作特征（ROC）分析，以找到最佳的截断值将 FCC 分为低和高 FCC 组，该截断值计算为 11.1 个细胞/100ml 血液。对于高 FCC 组，复合发病率的调整优势比（aOR）显著增加，aOR 为 1.6。
循环 TB 具有预测妊娠高血压疾病等产科并发症的潜力。未来的研究应着眼于这些细胞作为胎盘健康的生物标志物，并作为胎儿遗传疾病的可能筛查或诊断工具进行研究，样本量应更大。
