Kumar Jogender, Sundaram Venkataseshan, Gupta Kirti, Bhatia Anmol, Kaur Gurwinder, Dutta Sourabh
Post Graduate Institute of Medical Education & Research (PGIMER), Department of Pediatrics, Chandigarh, India.
Post Graduate Institute of Medical Education & Research (PGIMER), Department of Histopathology, Chandigarh, India.
Autops Case Rep. 2022 Jun 6;12:e2021386. doi: 10.4322/acr.2021.386. eCollection 2022.
We present a case of a late preterm intrauterine growth-restricted neonate with isolated and persistent severe thrombocytopenia. At birth, the neonate did not have a complete clinical spectrum of congenital rubella syndrome (CRS) but later developed peculiar findings that helped clinch the diagnosis. The neonate also had interstitial pneumonia and died secondary to superimposed acute viral infection leading to acute respiratory distress syndrome. The serology was positive for IgM antibodies against the rubella virus. The constellation of clinical manifestations of congenital rubella in the presence of positive IgM antibody against rubella and consistent histopathology confirmed the diagnosis of CRS.
我们报告一例晚期早产儿，其宫内生长受限，伴有孤立且持续的严重血小板减少症。出生时，该新生儿并无先天性风疹综合征（CRS）的完整临床症状，但后来出现了有助于确诊的特殊表现。该新生儿还患有间质性肺炎，继发于叠加的急性病毒感染，导致急性呼吸窘迫综合征。血清学检测显示风疹病毒IgM抗体呈阳性。在风疹IgM抗体阳性且组织病理学一致的情况下，先天性风疹的一系列临床表现确诊了CRS。
