Tyagi Swati, Mridha Asit Ranjan, Behera Chittaranjan
All India Institute of Medical Sciences, Department of Forensic Medicine & Toxicology, New Delhi, Delhi, India.
All India Institute of Medical Sciences, Department of Pathology, New Delhi, Delhi, India.
Autops Case Rep. 2022 May 27;12:e2021385. doi: 10.4322/acr.2021.385. eCollection 2022.
Ovarian Hyperstimulation Syndrome (OHSS) is uncommon among oocyte donors during in vitro fertilization (IVF) procedure and is rarely associated with death. We report a case of a 23-year-old oocyte donor who suddenly died on the operation table during oocyte retrieval. She had no risk factors in her menstrual history, laboratory, or clinical parameters. The antagonist cycle, triggered with the GnRH agonist protocol, was carried out. The cause of death at autopsy was attributed to respiratory failure due to acute massive pulmonary edema, which developed due to the complication of OHSS. Only a few autopsy cases associated with OHSS have been published, but, as far as we know, no clinical or autopsy cases of sudden death caused by OHSS have been reported.
卵巢过度刺激综合征（OHSS）在体外受精（IVF）过程中的卵母细胞捐赠者中并不常见，且很少与死亡相关。我们报告一例23岁的卵母细胞捐赠者，在取卵过程中突然死于手术台。她在月经史、实验室检查或临床参数方面均无危险因素。采用促性腺激素释放激素（GnRH）激动剂方案进行拮抗剂周期治疗。尸检结果显示，死亡原因是由于OHSS并发症导致的急性大量肺水肿引起的呼吸衰竭。仅有少数与OHSS相关的尸检病例被发表，但据我们所知，尚无OHSS导致猝死的临床或尸检病例报道。
