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食管梅毒

Syphilis in the Esophagus.

作者信息

Allencherril Ronan, Nicholls Paul, Jain Shilpa, Sealock Robert, Dangayach Priti

机构信息

Department of Internal Medicine, Baylor College of Medicine, Houston, TX.

Department of Infectious Diseases, Baylor College of Medicine, Houston, TX.

出版信息

ACG Case Rep J. 2022 Jun 24;9(6):e00793. doi: 10.14309/crj.0000000000000793. eCollection 2022 Jun.

DOI:10.14309/crj.0000000000000793
PMID:35765682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9232360/
Abstract

This report documents a unique case of syphilis with esophageal involvement. Such a presentation is exceedingly rare in the modern era, particularly among patients without human immunodeficiency virus. Most instances were documented in the 1900s and earlier. Our patient presented with months of odynophagia and recurrent oral lesions. He was found to have a sizeable esophageal ulcer on endoscopy, with biopsy confirming the diagnosis of syphilis. His symptoms quickly resolved with intramuscular penicillin. This case highlights the importance of keeping a broad differential for odynophagia and suspicious lesions, cutaneous or mucosal.

摘要

本报告记录了一例罕见的梅毒累及食管的病例。在现代,这种表现极为罕见,尤其是在未感染人类免疫缺陷病毒的患者中。大多数病例记录于20世纪及更早时期。我们的患者出现了数月的吞咽痛和复发性口腔病变。内镜检查发现他有一个较大的食管溃疡,活检确诊为梅毒。经肌肉注射青霉素后,他的症状迅速缓解。该病例强调了对吞咽痛以及皮肤或黏膜可疑病变进行广泛鉴别诊断的重要性。

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本文引用的文献

1
Syphilis Causing Lichenoid Esophagitis.梅毒引起苔藓样食管炎。
ACG Case Rep J. 2020 Jun 11;7(6):e00395. doi: 10.14309/crj.0000000000000395. eCollection 2020 Jun.
2
The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity.梅毒的免疫病理生物学:梅毒的表现和病程由迟发型超敏反应的水平决定。
Am J Dermatopathol. 2011 Jul;33(5):433-60. doi: 10.1097/DAD.0b013e3181e8b587.
3
Biological basis for syphilis.梅毒的生物学基础。
Clin Microbiol Rev. 2006 Jan;19(1):29-49. doi: 10.1128/CMR.19.1.29-49.2006.
4
Treponema pallidum and the quest for outer membrane proteins.梅毒螺旋体与外膜蛋白的探索
Mol Microbiol. 1995 Jun;16(6):1067-73. doi: 10.1111/j.1365-2958.1995.tb02332.x.