治疗相关急性髓系白血病中的罕见基因重排t(11;22)(q23;q13)/：一例报告 - Suppr

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超能文献

Rare Gene Rearrangement t(11;22)(q23;q13)/ in Therapy-related Acute Myeloid Leukemia: A Case Report.

作者信息

Kim Seo Wan, Lee Seungjae, Shin Saeam, Lee Seung-Tae

机构信息

Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.

出版信息

Ann Lab Med. 2022 Nov 1;42(6):693-696. doi: 10.3343/alm.2022.42.6.693.

DOI:10.3343/alm.2022.42.6.693

PMID:35765879

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277037/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64bc/9277037/5cf89cbcc5aa/alm-42-6-693-f1.jpg

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本文引用的文献

The First Korean Case of and a Novel Fusion in a Pediatric Therapy-related Acute Myeloid Leukemia Patient Detected by Targeted RNA Sequencing.通过靶向RNA测序在一名儿科治疗相关急性髓系白血病患者中检测到首例韩国病例及一种新型融合。

Ann Lab Med. 2021 Jul 1;41(4):443-446. doi: 10.3343/alm.2021.41.4.443.

An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review.一例罕见MLL-EP300重排的治疗相关髓系肿瘤潜伏期异常短暂：病例报告及文献综述

Case Rep Hematol. 2019 Oct 2;2019:4532434. doi: 10.1155/2019/4532434. eCollection 2019.

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis.Bcor 缺失扰乱髓系分化并促进白血病发生。

Nat Commun. 2019 Mar 22;10(1):1347. doi: 10.1038/s41467-019-09250-6.

-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.截断突变使造血细胞对化疗产生耐药性，并对 PPM1D 抑制敏感。

Blood. 2018 Sep 13;132(11):1095-1105. doi: 10.1182/blood-2018-05-850339. Epub 2018 Jun 28.

Novel variant form of t(11;22)(q23;q13)/MLL-EP300 fusion transcript in the evolution of an acute myeloid leukemia with myelodysplasia-related changes.

Leuk Res. 2011 Mar;35(3):e18-20. doi: 10.1016/j.leukres.2010.09.024. Epub 2010 Oct 25.

A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia.一种复杂的t(1;22;11)(q44;q13;q23)易位，在治疗相关急性髓系白血病中导致MLL-p300融合基因。

Eur J Haematol. 2008 Dec;81(6):475-80. doi: 10.1111/j.1600-0609.2008.01154.x. Epub 2008 Sep 6.

Menin critically links MLL proteins with LEDGF on cancer-associated target genes.Menin在癌症相关靶基因上把MLL蛋白与LEDGF紧密联系起来。

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.2C型磷酸酶Wip1：肿瘤抑制因子和DNA损伤反应通路的致癌调节因子。

Cancer Metastasis Rev. 2008 Jun;27(2):123-35. doi: 10.1007/s10555-008-9127-x.

An atlas of chromosomes in hematological malignancies. Example: 11q23 and MLL partners.血液系统恶性肿瘤染色体图谱。示例：11q23与混合谱系白血病基因（MLL）融合伙伴关系

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