甲基汞在体外和体内对氨酰腺苷酸合成的抑制作用。

Suppression of aminoacyladenylate synthesis by methyl mercury in vitro and in vivo.

作者信息

Kuznetsov D A, Zavijalov N V, Govorkov A V, Richter V

出版信息

Toxicol Lett. 1987 Apr;36(2):161-5. doi: 10.1016/0378-4274(87)90180-9.

Abstract

Methyl mercury (MeHg) at a concentration of 20 microM significantly inhibits the synthesis of aminoacyladenylates (AAA) in vitro from serine and histidine, and fails to inhibit AAA synthesis from phenylalanine, leucine, arginine and aspartate. In vivo administration of MeHg (single i.p. injection of 50 nmol/g body weight) leads to 75-80% suppression of AAA synthesis from serine, histidine, phenylalanine, leucine, arginine and aspartate in rat brain tissue.

摘要

浓度为20微摩尔的甲基汞（MeHg）在体外能显著抑制由丝氨酸和组氨酸合成氨酰腺苷酸（AAA），但不能抑制由苯丙氨酸、亮氨酸、精氨酸和天冬氨酸合成AAA。在体内给予甲基汞（单次腹腔注射50纳摩尔/克体重）会导致大鼠脑组织中由丝氨酸、组氨酸、苯丙氨酸、亮氨酸、精氨酸和天冬氨酸合成AAA的过程被抑制75 - 80%。