Trakya Üniversitesi, Cardiology Department - Edirne, Turquia.
Hatay Mustafa Kemal Üniversitesi, Cardiology Department - Antakya, Turquia.
Rev Assoc Med Bras (1992). 2022 Jun 24;68(6):792-796. doi: 10.1590/1806-9282.20211348. eCollection 2022.
Prealbumin has been a reliable marker to predict protein energy malnutrition and hypercatabolic state. In this analysis, we particularly aimed to investigate the potential association between serum prealbumin levels and right ventricular dysfunction in patients receiving programmed hemodialysis.
A total of 57 subjects were included in the analysis. The subjects were then categorized into two groups: right ventricular dysfunction (n=18) and non-right ventricular dysfunction (n=39) groups. In all patients, detailed transthoracic echocardiography (following hemodialysis) were performed along with the evaluation of complete blood count, routine biochemistry parameters, and, in particular, serum prealbumin levels.
Mortality rate at 3 years was found to be significantly higher in the right ventricular dysfunction group (p=0.042). Serum prealbumin levels were also significantly lower in the right ventricular dysfunction group compared with the non-right ventricular dysfunction group (23.83±8.50 mg/dL versus 31.38±6.81 mg/dL, p=0.001). In the receiver operating characteristics curve analysis, a prealbumin cutoff value of <28.5 mg/dL was found to predict right ventricular dysfunction, with a sensitivity of 67% and a specificity of 62% (area under the curve: 0.744). In the correlation analysis, a moderate yet significant positive correlation was demonstrated between serum prealbumin and tricuspid annular plane systolic excursion (r=0.365, p=0.005).
This study suggests that low serum prealbumin might serve as a potential predictor of right ventricular dysfunction (and its clinical consequences) in patients receiving programmed hemodialysis.
前白蛋白一直是预测蛋白质能量营养不良和高代谢状态的可靠标志物。在本分析中，我们特别旨在研究血清前白蛋白水平与接受程控血液透析患者右心室功能障碍之间的潜在关联。
共有 57 名受试者纳入分析。然后，将受试者分为两组：右心室功能障碍组（n=18）和非右心室功能障碍组（n=39）。在所有患者中，均进行详细的经胸超声心动图（在血液透析后），同时评估全血细胞计数、常规生化参数，特别是血清前白蛋白水平。
发现右心室功能障碍组的 3 年死亡率显著更高（p=0.042）。与非右心室功能障碍组相比，右心室功能障碍组的血清前白蛋白水平也显著降低（23.83±8.50 mg/dL 与 31.38±6.81 mg/dL，p=0.001）。在受试者工作特征曲线分析中，发现前白蛋白截断值<28.5 mg/dL 可预测右心室功能障碍，其敏感性为 67%，特异性为 62%（曲线下面积：0.744）。在相关性分析中，血清前白蛋白与三尖瓣环平面收缩期位移之间显示出中度但显著的正相关（r=0.365，p=0.005）。
本研究表明，血清前白蛋白水平降低可能是接受程控血液透析患者右心室功能障碍（及其临床后果）的潜在预测因子。
