Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, USA.
Department of Gastroenterology, Graduate school of Medicine, The University of Tokyo, Tokyo, Japan.
EMBO J. 2022 Jul 4;41(13):e111696. doi: 10.15252/embj.2022111696. Epub 2022 Jun 29.
R-spondins are critical regulators of gastric epithelial cells, with Lgr5 receptor historically considered as their main signaling transducer. Recent work by Wizenty et al (2022) now revealed distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.
R -spondins 是胃上皮细胞的关键调节因子，Lgr5 受体历史上被认为是它们的主要信号转导器。最近由 Wizenty 等人（2022 年）进行的工作现在揭示了 Lgr4 和 Lgr5 在指导幽门螺杆菌感染后腺体重建中的不同作用，这为胃再生过程中 Rspo 信号的复杂性提供了新的认识，并提出了关于胃窦干细胞层次结构的问题。
