Clinic of Endocrinology, University Hospital "Alexandrovska", Department of internal medicine, Medical University-Sofia, Bulgaria.
Iran J Immunol. 2022 Jun;19(2):193-200. doi: 10.22034/iji.2022.90095.1987.
Obesity and diabetes are related to chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions.
To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders.
This study included 387 Caucasians divided into four groups: healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics.
Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly high levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647).
Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.
肥胖和糖尿病与慢性低度炎症有关。白细胞介素-18（IL-18）作为一种促炎细胞因子，可刺激多种细胞类型，具有多种功能。
评估不同血糖异常人群中 IL-18 的水平。
本研究纳入了 387 名高加索人，分为 4 组：健康对照组、无碳水化合物问题的肥胖组、糖尿病前期患者和新发现的 2 型糖尿病患者。
体质指数（BMI）≥30kg/m2 且存在血糖异常的患者，其 IL-18 水平明显升高（249.77±89.96pg/ml、259.01±95.70pg/ml 和 340.98±127.65pg/ml），与对照组（219.47±110.53pg/ml）相比，差异有统计学意义（p<0.05）。IL-18 与部分人体测量参数、肝酶、空腹、餐后血糖、胰岛素、尿酸和甘油三酯呈正相关，与高密度脂蛋白（HDL）呈负相关。通过 ROC 分析确定了区分碳水化合物代谢紊乱和代谢综合征患者的循环 IL-18 水平。ROC 分析显示，碳水化合物代谢紊乱的 AUC 为 0.597（p=0.001；95%CI=0.539-0.654），代谢综合征的 AUC 为 0.581（p=0.021；95%CI=0.516-0.647）。
我们的数据表明，随着 IL-18 水平的升高，碳水化合物耐量恶化。然而，IL-18 在糖尿病的进展及其后续后果中的意义需要进一步探讨。
