循环 netrin-1 水平与肥胖、糖尿病前期和新诊断的 2 型糖尿病的关系。
Relationship between circulating netrin-1 levels, obesity, prediabetes and newly diagnosed type 2 diabetes.
机构信息
Department of Internal Medicine, Medical University, Sofia, Bulgaria.
Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Sofia, Bulgaria.
出版信息
Arch Physiol Biochem. 2022 Dec;128(6):1533-1538. doi: 10.1080/13813455.2020.1780453. Epub 2020 Jul 11.
BACKGROUND
Netrin-1 is presumed to have regenerative, angiogenic and anti-inflammatory properties, thus it could play a substantial role in the development of insulin resistance and T2DM.
OBJECTIVE
The aim of this study was to evaluate the relationship between serum netrin-1 levels and carbohydrate disturbances in patients with obesity.
METHODS
Sample size consisted of 163 patients, divided into four groups: obesity without carbohydrate disturbances prediabetes and diabetes and healthy controls Netrin-1 level was determined using ELISA method.
RESULTS
Circulating serum Netrin-1 was significantly lower in patients only with obesity, as well as with those with prediabetes and diabetes in comparison to the control group. Correlation analysis revealed that netrin-1 correlates negatively with BMI, waist, WSR, LDL and positive with sudomotor function. Netrin-1 ≤ 0.17 ng/ml has about 3 fold higher risk for carbohydrate disturbances (OR 3.06, 95% CI 1.48-6.34, = .003).
CONCLUSION
Netrin-1 is associated with an increased risk for glycaemic disorders in patients with obesity.
背景
轴突导向因子 1（Netrin-1）被认为具有再生、血管生成和抗炎特性，因此它可能在胰岛素抵抗和 T2DM 的发展中起重要作用。
目的
本研究旨在评估肥胖患者血清 Netrin-1 水平与碳水化合物紊乱之间的关系。
方法
样本量由 163 例患者组成，分为四组：肥胖无碳水化合物紊乱、前驱糖尿病和糖尿病以及健康对照组。采用 ELISA 法测定 Netrin-1 水平。
结果
与对照组相比，仅肥胖患者以及前驱糖尿病和糖尿病患者的循环血清 Netrin-1 水平显著降低。相关性分析显示，Netrin-1 与 BMI、腰围、WSR、LDL 呈负相关，与出汗功能呈正相关。Netrin-1≤0.17ng/ml 发生碳水化合物紊乱的风险增加约 3 倍（OR 3.06，95%CI 1.48-6.34，P=0.003）。
结论
Netrin-1 与肥胖患者的血糖紊乱风险增加相关。
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