Centre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
Centre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa.
BMJ Open. 2022 Jun 29;12(6):e060205. doi: 10.1136/bmjopen-2021-060205.
The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes.
Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set.
Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System.
This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.
西开普妊娠暴露登记处（PER）在南非西开普省的两个公立医疗机构哨点设立，以对妊娠期间的药物暴露及其与妊娠结局的相关性进行持续监测。
该登记处于 2016 年设立，所有在初级保健产科设施首次产前就诊的妇女均被纳入并随访至妊娠结局，无论其就诊的是初级、中级还是三级医疗机构。常规产科和医疗数据从医疗机构的临床记录中数字化。数据收集已整合到现有服务和信息平台中，并支持常规运作。PER 位于省级卫生数据中心内，该中心是一个信息交换中心，协调和整合了省内所有与健康相关的电子数据。数据通过唯一标识符进行链接贡献。这种关系限制了 PER 中的缺失数据，允许在人群水平数据集进行验证和避免分类错误。
每年约有 5000 名和 3500 名孕妇分别进入城市和农村地区的数据组。截至 2021 年 8 月，已记录了超过 30000 例妊娠，其中 93%的妊娠结局已经确定。从 PER 中得出的关键产科和新生儿健康指标的分析结果与地区卫生信息系统的汇总数据一致。
这代表着一个重要的基础设施，能够解决中低收入环境中的临床和流行病学问题。
