Petraglia A, Cecere L, Scarpitta M, Ansalone D
Minerva Med. 1979 Jan 31;70(5):405-11.
The key-points of the physiopathological treatment of chronic pneumogenous respiratory insufficiency are: correction of distribution defects, suitable local adjustment of the ventilation: perfusion ratio, and correction of obstacles to alveolocapillary diffusion. Many drugs can be used to obtain these results; bronchodilators, vasoactive drugs, cortisones, cardiokinetics, antibiotics, analeptics. Reference is also made to oxygen therapy, depletion management (bloodletting and-or diuretics, and their possible mechanisms. Lastly, attention is given to disturbances, in acid-base equilibrium in chronic respiratory insufficiency and their correction.
纠正分布缺陷，对通气与灌注比例进行适当的局部调整，以及纠正肺泡-毛细血管扩散障碍。可使用多种药物来达到这些效果；支气管扩张剂、血管活性药物、皮质激素、强心药、抗生素、兴奋剂。文中还提及了氧疗、排液处理（放血和/或使用利尿剂）及其可能的机制。最后，关注慢性呼吸功能不全时的酸碱平衡紊乱及其纠正。
