Kirste Guenter
Department of Surgery, University Hospital of Freiburg, Albert Ludwig University of Freiburg, Freiburg im Breisgau, Germany.
Korean J Transplant. 2022 Mar 31;36(1):2-14. doi: 10.4285/kjt.22.0008.
Transplantation is the method of choice and, in many cases, the only method of treatment for patients with end-stage organ disease. Excellent results have been achieved, and the main focus today is to extend the number of available donors. The use of extended-criteria donors or donors after circulatory death is standard, but is accompanied by an increased risk of ischemia reperfusion injury. This review presents newly developed machine perfusion techniques using hypothermic, subnormothermic, or normothermic conditions, with or without oxygenation. Possibilities for treatment and quality assessment in decision-making about organ acceptability are also discussed.
移植是终末期器官疾病患者的首选治疗方法，在许多情况下也是唯一的治疗方法。目前已取得了出色的成果，而如今的主要重点是增加可用供体的数量。使用扩大标准供体或循环死亡后供体已成为标准做法，但这伴随着缺血再灌注损伤风险的增加。本综述介绍了新开发的机器灌注技术，这些技术采用低温、亚常温或常温条件，有无氧合均可。还讨论了在器官可接受性决策中的治疗可能性和质量评估。
