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小儿活体肝移植中腹腔镜获取左肝移植物流出道肝静脉的联合血管成形术

Unification venoplasty of the outflow hepatic vein for laparoscopically harvested left liver grafts in pediatric living donor liver transplantation.

作者信息

Namgoong Jung-Man, Hwang Shin, Kim Ki-Hun, Park Gil-Chun, Kim Kyung Mo, Oh Seak Hee, Cho Hwui-Dong, Kwon Hyunhee, Kwon Yong Jae

机构信息

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Korean J Transplant. 2020 Dec 31;34(4):293-301. doi: 10.4285/kjt.20.0027. Epub 2020 Dec 16.

Abstract

Laparoscopically harvested left liver (LL) grafts have drawbacks with respect to the size and shape of graft hepatic vein orifices. We present two cases of pediatric living donor liver transplantation (LDLT) using laparoscopically harvested LL grafts and describe refined surgical techniques for graft hepatic vein venoplasty. The first case was a boy aged 4 years and 5 months, with hepatoblastoma. The donor was his 35-year-old mother, and LL graft weighed 315 g. Two separate openings of the graft at the left hepatic vein (LHV) and middle hepatic vein (MHV) were unified through septotomy and septoplasty, and cryopreserved vein homograft patch was attached. Standard procedures of LDLT were performed. This patient recovered uneventfully and has been doing well for 4 years without tumor recurrence. The second case was a 6-year-old girl with ornithine transcarbamylase deficiency. The donor was her 35-year-old mother, and the LL graft weighed 310 g. Two separate openings of graft MHV, with segment III and segment II veins, were unified through septoplasty, and vein patch was attached. Standard procedures of LDLT were performed. This patient has been doing well for 4 years. In conclusion, separate graft hepatic vein openings are a drawback of laparoscopically harvested LL grafts, which thus require unification venoplasty of customized design individually tailored for LL graft and pediatric recipient.

摘要

腹腔镜获取的左肝(LL)移植物在移植物肝静脉开口的大小和形状方面存在缺陷。我们报告了两例使用腹腔镜获取的LL移植物进行小儿活体肝移植(LDLT)的病例,并描述了用于移植物肝静脉成形术的改良手术技术。第一例是一名4岁5个月大的男孩,患有肝母细胞瘤。供体是他35岁的母亲,LL移植物重315克。通过隔膜切开术和隔膜成形术将移植物在左肝静脉(LHV)和中肝静脉(MHV)处的两个独立开口合并,并附上冷冻保存的静脉同种异体补片。进行了LDLT的标准手术程序。该患者恢复顺利,4年来一直状况良好,无肿瘤复发。第二例是一名6岁女孩,患有鸟氨酸转氨甲酰酶缺乏症。供体是她35岁的母亲,LL移植物重310克。通过隔膜成形术将移植物MHV与Ⅲ段和Ⅱ段静脉的两个独立开口合并,并附上静脉补片。进行了LDLT的标准手术程序。该患者4年来一直状况良好。总之,移植物肝静脉开口分离是腹腔镜获取的LL移植物的一个缺陷,因此需要针对LL移植物和小儿受者进行个体化定制设计的统一静脉成形术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6805/9186964/505937f3cf81/KJT-34-4-293-f8.jpg

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