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术后针刺与术前针刺或美洛昔康对行卵巢子宫切除术犬同样有效:一项盲法随机研究。

Postoperative Acupuncture is as Effective as Preoperative Acupuncture or Meloxicam in Dogs Undergoing Ovariohysterectomy: a Blind Randomized Study.

机构信息

School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Jaú Pet Care, Jaú, São Paulo, Brazil.

出版信息

J Acupunct Meridian Stud. 2022 Jun 30;15(3):181-188. doi: 10.51507/j.jams.2022.15.3.181.

Abstract

BACKGROUND

Acupuncture has the same analgesic effect as non-steroidal antiinflammatory drugs and opioids. It is challenging to perform preoperative acupuncture in unmanageable animals, while the residual postoperative anesthetic effect facilitates the performance of acupuncture postoperatively.

OBJECTIVES

To compare preoperative acupuncture or meloxicam versus postoperative acupuncture for postoperative analgesia after ovariohysterectomy.

METHODS

This is a horizontal prospective positive control blind randomized experimental study. Thirty-six dogs were randomly divided into three groups: GA (preemptive acupuncture), GPA (postoperative acupuncture), and GM (meloxicam 0.2 mg/kg IV preoperatively). After sedation with acepromazine (0.05 mg/kg IM), anesthesia was induced with propofol (5.3 ± 0.3 mg/kg) and maintained with isoflurane/O2. Fentanyl (2 μg/kg, IV) was administered immediately before surgery. Bilateral acupuncture was performed at acupoints Large intestine 4, Spleen 6, and Stomach 36 for 20 minutes, before (GA) or immediately after surgery (GPA). Pain was evaluated by an observer blind to the treatment using the Glasgow scale before and for 24 hours after ovariohysterectomy. Dogs with a score ≥ 6 received rescue analgesia with morphine (0.5 mg/kg IM). Nonparametric data were analyzed by the Kruskal-Wallis test, followed by Dunn's test and parametric data by ANOVA followed by Tukey's test.

RESULTS

Two GA and one GPA dogs received rescue analgesia once. Two GM dogs received rescue analgesia and one of those was treated again twice. There were no differences in the number of dogs receiving rescue analgesia between groups (p = 0.80).

CONCLUSION

Postoperative acupuncture was as effective as preoperative acupuncture or meloxicam in female dogs undergoing ovariohysterectomy.

摘要

背景

针灸具有与非甾体抗炎药和阿片类药物相同的镇痛效果。在难以管理的动物中进行术前针灸具有挑战性,而术后残留的麻醉效果有利于术后进行针灸。

目的

比较术前针灸或美洛昔康与术后针灸在卵巢子宫切除术(OHE)后术后镇痛中的效果。

方法

这是一项横向前瞻性阳性对照盲随机实验研究。36 只狗被随机分为三组:GA(预防性针灸)、GPA(术后针灸)和 GM(术前静脉注射 0.2mg/kg 美洛昔康)。在肌肉注射乙酰丙嗪(0.05mg/kg)镇静后,用丙泊酚(5.3±0.3mg/kg)诱导麻醉,并使用异氟烷/O2 维持。手术前立即给予芬太尼(2μg/kg,IV)。在双侧大肠 4、脾 6 和胃 36 穴位上进行 20 分钟的针灸,在手术前(GA)或手术后立即(GPA)进行。在 OHE 前后 24 小时,通过观察者对治疗进行盲法评估,使用格拉斯哥评分评估疼痛。得分≥6 的狗接受肌肉注射吗啡(0.5mg/kg)进行解救性镇痛。非参数数据采用 Kruskal-Wallis 检验进行分析,然后采用 Dunn 检验,参数数据采用 ANOVA 检验,然后采用 Tukey 检验。

结果

2 只 GA 和 1 只 GPA 狗各接受了 1 次解救性镇痛。2 只 GM 狗接受了解救性镇痛,其中 1 只再次接受了 2 次治疗。各组接受解救性镇痛的狗的数量没有差异(p=0.80)。

结论

在接受 OHE 的雌性狗中,术后针灸与术前针灸或美洛昔康一样有效。

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