从.中分离得到的两种具有 NO 抑制活性的新愈创木烷型倍半萜。
Two new guaianolide-type sesquiterpenoids with NO inhibitory activity from .
机构信息
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
出版信息
J Asian Nat Prod Res. 2023 Apr;25(4):316-323. doi: 10.1080/10286020.2022.2091991. Epub 2022 Jun 30.
Two new guaianolide-type sesquiterpenoids chrysanthemulides K and L ( and ), together with six known analogues (-), were isolated from an CHCl extract of the aerial parts of . The structures of new compounds and were established by extensive spectroscopic analysis, including UV, IR, MS, NMR and computational electronic circular dichroism (ECD) methods. Inhibitory effects of all compounds on nitric oxide production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds - displayed NO production inhibitory activity with IC50 values ranged from 3.5 to 34.3 µM.
从 Chrysanthemum zawadskii 的地上部分的 CHCl3 提取物中分离得到了两种新的愈创木烷型倍半萜类化合物 chrysanthemulides K 和 L（和），以及 6 种已知类似物（-）。通过广泛的光谱分析，包括 UV、IR、MS、NMR 和计算电子圆二色性（ECD）方法，确定了新化合物和的结构。所有化合物对脂多糖（LPS）诱导的 RAW 264.7 细胞中一氧化氮（NO）生成的抑制作用进行了研究。结果表明，化合物-对 NO 生成具有抑制活性，IC50 值范围为 3.5 至 34.3 μM。
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