来自宽叶菊（Dendranthema zawadskii var. latilobum）的倍半萜及其他成分。
Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum.
作者信息
Shin Hyun Jung, Lee So Young, Kim Ju Sun, Lee Sanghyun, Choi Ran Joo, Chung Ha Sook, Kim Yeong Shik, Kang Sam Sik
机构信息
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea.
出版信息
Chem Pharm Bull (Tokyo). 2012;60(3):306-14. doi: 10.1248/cpb.60.306.
Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (-)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 μM, respectively.
从宽叶菊苣的地上部分分离出6种新的吉马烷型倍半萜内酯，即紫花菊内酯A - F（1 - 6），以及1种新的桉烷型葡萄糖苷，即菊苣叶苷（7），同时还分离出13种已知成分。通过光谱证据阐明了它们的结构。生物活性测定表明，芹菜素（9）、（-）-圣草酚（10）和尼泊尔黄酮素（12）等黄酮类化合物，以及倍半萜内酯紫花菊内酯F（6），均可抑制脂多糖（LPS）刺激的RAW 264.7巨噬细胞中一氧化氮（NO）的产生，其IC50值分别为66.15、132.55、35.44和91.32μM。
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