Bao Zhi-Hang, Hou Xiang-Bin, Li Hao-Ling, Mao Yi-Feng, Wang Wen-Rui
Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Anhui 233030, China; Department of Clinical Medicine, Bengbu Medical College, Anhui 233030, China.
Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Anhui 233030, China; Department of Life Sciences, Bengbu Medical College, Anhui 233030, China.
Acta Histochem. 2022 Aug;124(6):151919. doi: 10.1016/j.acthis.2022.151919. Epub 2022 Jun 27.
Pancreatic cancer is one of the deadliest cancers in the world, causing hundreds of thousands of deaths worldwide annually. Because of late diagnosis, rapid metastasis and drug resistance to chemotherapy, pancreatic cancer has a poor prognosis. Although the treatment of pancreatic cancer has made tremendous progress, the options for effective treatment are still limited, and new treatment methods are in crying needs to improve prognosis in clinic. Ferroptosis is an iron-dependent non-apoptotic cell death mode, which is mediated by lipid peroxidation and iron accumulation. Ferroptosis plays a momentous role in regulating different cancers in recent years, such as breast cancer, hepatocellular carcinoma, lung cancer and pancreatic cancer. In this present review, we elaborate on the regulatory mechanisms and signaling pathways of ferroptosis in pancreatic cancer, with the intention of delivering directions and new ideas for the treatment of pancreatic cancer.
胰腺癌是世界上最致命的癌症之一，每年在全球导致数十万人死亡。由于诊断延迟、快速转移以及对化疗的耐药性，胰腺癌的预后很差。尽管胰腺癌的治疗取得了巨大进展，但有效治疗的选择仍然有限，迫切需要新的治疗方法来改善临床预后。铁死亡是一种铁依赖性非凋亡性细胞死亡模式，由脂质过氧化和铁积累介导。近年来，铁死亡在调节不同癌症（如乳腺癌、肝细胞癌、肺癌和胰腺癌）中发挥着重要作用。在本综述中，我们阐述了胰腺癌中铁死亡的调节机制和信号通路，旨在为胰腺癌的治疗提供方向和新思路。
