Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa machi, Maebashi, Gunma, 371-8511, Japan.
Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Sci Rep. 2022 Jun 30;12(1):11092. doi: 10.1038/s41598-022-15381-6.
The study investigated clinical features of sellar and suprasellar tumors with optic nerve bending. Twenty-five patients (13 men/12 women; age, 59.0 ± 12.9 years) with optic nerve bending in one eye who underwent tumor resection for sellar and suprasellar tumors were included. The other eye, without optic nerve bending, was the control. The pre- and postoperative best-corrected visual acuity (BCVA) and ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness were studied retrospectively using optical coherence tomography. Preoperative BCVA in the eye with optic nerve bending was significantly poor and improved significantly after tumor resection. Eyes with optic nerve bending had significantly less GCL + IPL thickness on the temporal side than eyes without optic nerve bending. Preoperative GCL + IPL thickness of the entire macula was reduced in eyes with optic nerve bending and poor postoperative BCVA compared to those with good postoperative BCVA. There was no significant difference in GCL + IPL thickness of eyes with optic nerve bending before and after tumor resection. Optic nerve bending caused by sellar and suprasellar tumors resulted in visual impairment and decreased retinal ganglion cells. Eyes with optic nerve bending and severely reduced GCL + IPL thickness may have less BCVA improvement after tumor resection.
本研究调查了伴有视神经弯曲的鞍区和鞍上肿瘤的临床特征。共纳入 25 例（男 13 例，女 12 例；年龄 59.0±12.9 岁）因鞍区和鞍上肿瘤行肿瘤切除术的伴有一眼视神经弯曲的患者。另一眼无视神经弯曲作为对照。使用光学相干断层扫描对术前和术后最佳矫正视力（BCVA）和节细胞层（GCL）+内丛状层（IPL）厚度进行回顾性研究。伴有视神经弯曲眼的术前 BCVA 明显较差，肿瘤切除后明显改善。伴有视神经弯曲眼的颞侧 GCL+IPL 厚度明显小于无视神经弯曲眼。与术后 BCVA 良好的患者相比，伴有视神经弯曲和较差术后 BCVA 的患者的整个黄斑区术前 GCL+IPL 厚度减少。伴有视神经弯曲眼肿瘤切除前后 GCL+IPL 厚度无明显差异。鞍区和鞍上肿瘤引起的视神经弯曲导致视力障碍和视网膜神经节细胞减少。伴有视神经弯曲和 GCL+IPL 厚度严重减少的眼，肿瘤切除后 BCVA 改善可能较小。
