DNA双链断裂修复基因XRCC5、LIG4多态性与胶质瘤的相关性

[Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma].

作者信息

He Peng, Li Ran, Luo Wenkai, Meng Lingsong

机构信息

Department of Neurosurgery, Anyang People's Hospital, Anyang, Henan 455000, China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2022 Jun 10;39(6):641-645.

PMID:35773772

Abstract

OBJECTIVE

To assess the association of DNA double-strand break repair genes XRCC5 and LIG4 with glioma.

METHODS

126 patients with glioma (case group) and 120 healthy volunteers (control group) were enrolled. The polymorphisms of XRCC5 loci rs828704 and rs9288516, LIG4 loci rs3093737, rs3093739 and rs10131 were detected, and their association with the susceptibility to glioma was analyzed.

RESULTS

Hardy-Weinberg test showed that XRCC5 loci rs828704 and rs9288516, LIG4 loci rs3093737, rs3093739 and rs10131 were in equilibrium in both groups (P>0.05). The frequency of A allele of XRCC5 gene rs9288516 locus and T allele of LIG4 gene rs10131 locus in the case group was higher than that in the control group (P<0.05). XRCC5 rs9288516 and LIG4 rs10131 were associated with the susceptibility to glioma under both recessive and additive models (P<0.05), while LIG4 rs3093739 was associated with susceptibility to glioma under the recessive model (P<0.05).

CONCLUSION

XRCC5 rs9288516 and LIG4 rs10131 are associated with the susceptibility to glioma. Above finding may provide a reference for the prevention and treatment of glioma.

摘要

目的

评估DNA双链断裂修复基因XRCC5和LIG4与胶质瘤的关联。

方法

纳入126例胶质瘤患者（病例组）和120名健康志愿者（对照组）。检测XRCC5基因座rs828704和rs9288516、LIG4基因座rs3093737、rs3093739和rs10131的多态性，并分析它们与胶质瘤易感性的关联。

结果

Hardy-Weinberg检验显示，两组中XRCC5基因座rs828704和rs9288516、LIG4基因座rs3093737、rs3093739和rs10131均处于平衡状态（P>0.05）。病例组中XRCC5基因rs9288516位点的A等位基因频率和LIG4基因rs10131位点的T等位基因频率高于对照组（P<0.05）。在隐性和加性模型下，XRCC5 rs9288516和LIG4 rs10131均与胶质瘤易感性相关（P<0.05），而LIG4 rs3093739在隐性模型下与胶质瘤易感性相关（P<0.05）。