Nath Moumita, Debnath Pradip
Department of Botany, Tripura University, Suryamaninagar, Tripura, India.
Department of Chemistry, Maharaja Bir Bikram College, Agartala, Tripura, India.
J Biomol Struct Dyn. 2023 Jul-Aug;41(12):5894-5913. doi: 10.1080/07391102.2022.2093793. Epub 2022 Jun 30.
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is a big challenge and burning issue to the scientific community and doctors worldwide. Globally, COVID-19 has created a health disaster and adversely affects the economic growth. Although some vaccines have already emerged, no therapeutic medication has yet been approved by FDA for the treatment of COVID-19 patients. Traditionally, we have been using different medicinal plants like neem, tulsi, tea, and many spices like garlic, ginger, turmeric, black seed, onion, etc. for the treatment of flu-like diseases. In this paper, we are highlighting the recent research progress in the identification of natural products from the Indian medicinal plants and spices that have potential inhibition properties against SARS-CoV-2. This study will provide an initiative to stimulate further research by providing useful guidance to the medicinal chemists for designing new protease inhibitors effective against SARS-CoV-2 in future.Communicated by Ramaswamy H. Sarma.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的冠状病毒病（COVID-19）对全球科学界和医生来说是一个巨大挑战和紧迫问题。在全球范围内，COVID-19造成了一场健康灾难，并对经济增长产生了不利影响。尽管已经出现了一些疫苗，但尚无治疗药物获得美国食品药品监督管理局（FDA）批准用于治疗COVID-19患者。传统上，我们一直在使用不同的药用植物，如印楝、罗勒、茶，以及许多香料，如大蒜、生姜、姜黄、黑种草籽、洋葱等，来治疗流感样疾病。在本文中，我们重点介绍了从印度药用植物和香料中鉴定出具有潜在抑制SARS-CoV-2特性的天然产物的最新研究进展。本研究将通过为药物化学家未来设计有效对抗SARS-CoV-2的新型蛋白酶抑制剂提供有用指导，为推动进一步研究提供契机。由拉马斯瓦米·H·萨尔马通讯。
