采用注射外泌体治疗复发性坐骨溃疡。
Treatment of a recurrent ischial ulcer with injected exosomes.
作者信息
Messa Genevieve E, Tiongco Rafael P, Lau Frank H
机构信息
Department of Surgery, Louisiana State University Health Sciences Center New Orleans (LSUHSC-NO), New Orleans, LA, USA.
Tulane University School of Medicine, New Orleans, LA, USA.
出版信息
J Surg Case Rep. 2022 Jun 28;2022(6):rjac271. doi: 10.1093/jscr/rjac271. eCollection 2022 Jun.
Pressure ulcers (PUs) affect 2.5 million patients per year. Even after successful reconstruction, 50% of PUs recur. Patients with multiply recurrent PUs eventually consume all locoregional donor sites. This underscores the need for novel, less invasive approaches in PU reconstruction. Here, we report the first successful use of mesenchymal stem cell exosomes in PU reconstruction. The patient presented with a right ischial ulcer that persisted despite 9 months of wound care and appropriate antibiotic therapy. After six subcutaneous ExoFlo exosome injections over 8 weeks, the PU was completely healed. Additional studies of this promising technology should be performed.
每年有250万患者受压力性溃疡（PU）影响。即使成功重建后，50%的压力性溃疡仍会复发。多次复发的压力性溃疡患者最终会用尽所有局部供区。这凸显了在压力性溃疡重建中采用新颖、侵入性较小方法的必要性。在此，我们报告间充质干细胞外泌体首次成功用于压力性溃疡重建。该患者患有右坐骨溃疡，尽管经过9个月的伤口护理和适当的抗生素治疗仍未愈合。在8周内进行6次皮下注射ExoFlo外泌体后，压力性溃疡完全愈合。应对这项有前景的技术开展更多研究。
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