State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
Front Immunol. 2022 Jun 14;13:921366. doi: 10.3389/fimmu.2022.921366. eCollection 2022.
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-β.
激活素 A 是转化生长因子-β（TGF-β）超家族的重要成员，是一种多能因子，参与过敏、自身免疫性疾病、癌症和其他免疫紊乱疾病。与家族成员 TGF-β 类似，激活素 A 也通过 SMAD2/SMAD3 传递信号，但其与不同的受体结合。最近的研究揭示，激活素 A 在先天和适应性免疫系统中都发挥着关键作用。在这里，我们主要关注它对免疫系统中不可或缺的细胞的激活、分化、增殖和功能的影响，并与 TGF-β 的影响进行一些比较。
