乳腺癌患者的复发风险与基因多态性有关：伊朗人群样本中的前瞻性研究。

The risk of relapse in breast cancer patients is associated with gene polymorphism: a prospective study in a sample of the Iranian population.

机构信息

Department of biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran.

Young Researchers and Elite Club, Islamic Azad University, Arsanjan, Iran.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2022;41(10):1012-1023. doi: 10.1080/15257770.2022.2094946. Epub 2022 Jul 1.

DOI:10.1080/15257770.2022.2094946

PMID:35776084

Abstract

We investigated the association of rs1056628 and rs17576 polymorphisms with breast cancer (BC) relapse in a cohort of prospectively observed BC patients. The polymorphisms were genotyped in 200 BC subjects with(case) and without(control) relapse by Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) method. A significant association was found between the rs1056628C allele and increased risk of BC relapse (OR = 1.8, = 0.006). Also, rs17576 allele and genotypes were shown protective effects against BC relapse. Increased risk of relapse was observed in haplotype CG (OR = 2.1, = 0.001). Our results suggest for the first time that rs1056628 and rs17576 polymorphisms may influence BC relapse.

摘要

我们调查了 rs1056628 和 rs17576 多态性与前瞻性观察的乳腺癌（BC）患者队列中 BC 复发的关联。通过 Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) 方法，对 200 名有（病例）和无（对照）复发的 BC 患者进行了 rs1056628 和 rs17576 多态性的基因分型。rs1056628C 等位基因与 BC 复发风险增加显著相关（OR=1.8，=0.006）。此外，rs17576 等位基因和基因型显示出对 BC 复发的保护作用。CG 单倍型增加了复发风险（OR=2.1，=0.001）。我们的研究结果首次表明，rs1056628 和 rs17576 多态性可能影响 BC 的复发。