Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Methods Mol Biol. 2022;2510:53-63. doi: 10.1007/978-1-0716-2384-8_3.
For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma membrane permeability, eventually leading to cell death. However, later studies revealed that controlled P2X7R activation has beneficial effects on cell metabolism and nowadays our perception of the physiological role of this receptor has radically changed. Some of the biochemical pathways underlying the trophic effect of the P2X7R are being unveiled, thus disclosing an unanticipated role of P2X7Rs in mitochondrial and glycolytic metabolism. We provide here an update of the effects of the P2X7R on cell energy metabolism.
多年来，由于其能够引起质膜通透性的剧烈变化，最终导致细胞死亡，P2X7 受体（P2X7R）被认为是典型的细胞溶解受体。然而，后来的研究表明，P2X7R 的受控激活对细胞代谢有有益的影响，而如今我们对该受体的生理作用的认识已经发生了根本性的变化。P2X7R 营养作用的一些生化途径正在被揭示，从而揭示了 P2X7Rs 在线粒体和糖酵解代谢中的意想不到的作用。我们在这里提供 P2X7R 对细胞能量代谢影响的最新信息。
