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Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association.

作者信息

Sargunas Paul R, Spangler Jamie B

机构信息

Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

出版信息

Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2208330119. doi: 10.1073/pnas.2208330119. Epub 2022 Jul 1.

DOI:10.1073/pnas.2208330119
PMID:35776537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282379/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d803/9282379/0ce24795f755/pnas.2208330119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d803/9282379/0ce24795f755/pnas.2208330119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d803/9282379/0ce24795f755/pnas.2208330119fig01.jpg

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本文引用的文献

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Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2201562119. doi: 10.1073/pnas.2201562119. Epub 2022 Jun 2.
2
Facile discovery of surrogate cytokine agonists.替代细胞因子激动剂的简便发现。
Cell. 2022 Apr 14;185(8):1414-1430.e19. doi: 10.1016/j.cell.2022.02.025. Epub 2022 Mar 23.
3
Agonist antibody discovery: Experimental, computational, and rational engineering approaches.
激动剂抗体的发现:实验、计算和合理的工程方法。
Drug Discov Today. 2022 Jan;27(1):31-48. doi: 10.1016/j.drudis.2021.09.008. Epub 2021 Sep 24.
4
Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods.采用新兴的实验和计算方法进行药物样抗体的发现阶段鉴定。
MAbs. 2021 Jan-Dec;13(1):1895540. doi: 10.1080/19420862.2021.1895540.
5
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.糖基反应性 Fab 二聚体抗体是天然抗体的一种结构类别。
Cell. 2021 May 27;184(11):2955-2972.e25. doi: 10.1016/j.cell.2021.04.042. Epub 2021 May 20.
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FDA approves 100th monoclonal antibody product.美国食品药品监督管理局批准第100种单克隆抗体产品。
Nat Rev Drug Discov. 2021 Jul;20(7):491-495. doi: 10.1038/d41573-021-00079-7.
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Int J Mol Sci. 2021 Apr 16;22(8):4123. doi: 10.3390/ijms22084123.
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Enhanced SARS-CoV-2 neutralization by dimeric IgA.二聚体 IgA 增强对 SARS-CoV-2 的中和作用。
Sci Transl Med. 2021 Jan 20;13(577). doi: 10.1126/scitranslmed.abf1555. Epub 2020 Dec 7.
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