Department of epidemiology and health statistics, School of public health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Medical record room, Xinjiang Medical University Affiliated Third Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China.
Infect Genet Evol. 2022 Sep;103:105324. doi: 10.1016/j.meegid.2022.105324. Epub 2022 Jun 28.
Tuberculosis (TB) treatment is associated with Vitamin D. This study aimed to explore the relationship between Vitamin D receptor (VDR) gene polymorphisms and second acid-fast bacilli (AFB) smear-positive during treatment for TB patients.
This was a cross-sectional study. Seven hundred and thirty-one TB patients whose single nucleotide polymorphism site (SNPs) of VDR gene were detected from December 2019 to December 2020 in XinJiang of China. The genotypic distributions in each group were tested separately for Hardy-Weinberg equilibrium. The tetragram test was used to construct haplotypes to evaluate the association between each haplotype and second AFB smear-positive occurrence.
No significant deviations were observed with all the four polymorphism sites in the genotypic distributions (P>0.05). Linkage disequilibrium (LD) analysis showed that there was LD between SNPs of VDR gene (r=0.74, D`>0.9). Each haplotype was not considered to be the influencing factor of second AFB smear-positive.
There is no association between VDR gene polymorphism (ApaI, BsmI, FokI and TaqI) and second AFB smear-positive.
结核病（TB）的治疗与维生素 D 有关。本研究旨在探讨维生素 D 受体（VDR）基因多态性与 TB 患者治疗期间第二次酸性快速分枝杆菌（AFB）涂片阳性之间的关系。
这是一项横断面研究。从 2019 年 12 月至 2020 年 12 月，在中国新疆对 731 例 VDR 基因单核苷酸多态性（SNP）检测的 TB 患者进行研究。分别检测每组的基因型分布是否符合 Hardy-Weinberg 平衡。四联体试验用于构建单体型，以评估每个单体型与第二次 AFB 涂片阳性发生之间的关系。
所有四个多态性位点的基因型分布均无明显偏离（P>0.05）。连锁不平衡（LD）分析显示 VDR 基因的 SNP 之间存在 LD（r=0.74，D`>0.9）。每个单体型不被认为是第二次 AFB 涂片阳性的影响因素。
VDR 基因多态性（ApaI、BsmI、FokI 和 TaqI）与第二次 AFB 涂片阳性之间无关联。
