Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.
Sci Total Environ. 2022 Oct 20;844:157028. doi: 10.1016/j.scitotenv.2022.157028. Epub 2022 Jun 28.
To investigate the associations of arsenic exposure with lung function and ventilatory impairment. The repeated-measures study was developed with 8479 observations from three study periods of the Wuhan-Zhuhai cohort. Urinary arsenic and lung function were measured during each period. Linear mixed models were used to estimate the cross-sectional and longitudinal relationships between urinary arsenic and lung function. Logistic regression models and COX regression models were used to evaluate the cross-sectional and longitudinal associations between urinary arsenic and ventilatory impairment, respectively. In the cross-sectional analysis, each 1-unit increase in log-transformed urinary arsenic was associated with a -22.499 mL (95 % confidence interval (CI): -35.832 to -9.165), -15.081 mL (-25.205 to -4.957), and -0.274 % (-0.541 to -0.007) change in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC, respectively. In the longitudinal analysis, each 1-unit increase in log-transformed urinary arsenic was associated with an annual change rate of -6.240 mL/year (95 % CI: -12.429 to -0.051), -5.855 mL/year (-10.632 to -1.079), and -0.143 %/year (-0.234 to -0.051) in FVC, FEV1, and FEV1/FVC, respectively. Stratified analyses suggested a modification role of gender on the cross-sectional and longitudinal associations between urinary arsenic and FEV1, with the stronger associations were found among males (P for modification 0.0384 and 0.0168). Furtherly, each 1-unit increase in log-transformed urinary arsenic was associated with a 14.8 % (odds ratio 1.148, 95 % CI: 1.043 to 1.263) and 11.7 % (hazard ratio 1.117, 95 % CI: 1.023 to 1.218) increase in the prevalent and incident risk of restrictive ventilatory impairment, respectively. Source analyses suggested that fish intake and fine particulate matter inhalation positively associated with the total arsenic levels. In conclusion, arsenic exposure was associated with lung function decline and the risk of restrictive ventilatory impairment.
探讨砷暴露与肺功能和通气损害的关联。本重复测量研究纳入了武汉-珠海队列的三个研究期间的 8479 次观察结果。在每个期间测量尿砷和肺功能。采用线性混合模型估计尿砷与肺功能之间的横断面和纵向关系。采用 logistic 回归模型和 COX 回归模型分别评估尿砷与通气损害的横断面和纵向关联。在横断面分析中，尿砷的自然对数值每增加 1 个单位，用力肺活量（FVC）、1 秒用力呼气量（FEV1）和 FEV1/FVC 分别降低 22.499 毫升（95%置信区间（CI）：-35.832 至-9.165）、15.081 毫升（-25.205 至-4.957）和 0.274%（-0.541 至-0.007）。在纵向分析中，尿砷的自然对数值每增加 1 个单位，FVC、FEV1 和 FEV1/FVC 的年变化率分别为-6.240 毫升/年（95%CI：-12.429 至-0.051）、-5.855 毫升/年（-10.632 至-1.079）和-0.143%/年（-0.234 至-0.051）。分层分析表明，性别对尿砷与 FEV1 之间的横断面和纵向关联具有调节作用，男性的关联更强（P 修饰值分别为 0.0384 和 0.0168）。进一步，尿砷的自然对数值每增加 1 个单位，与流行和新发限制性通气损害的风险分别增加 14.8%（比值比 1.148，95%CI：1.043 至 1.263）和 11.7%（风险比 1.117，95%CI：1.023 至 1.218）。来源分析表明，鱼类摄入和细颗粒物吸入与总砷水平呈正相关。结论：砷暴露与肺功能下降和限制性通气损害风险增加有关。
