BK 多瘤病毒大 T 抗原对肾移植受者 CD4 和 CD8 T 细胞的影响。
The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients.
机构信息
Biology Department, Science and Arts University, Yazd, Iran.
Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Transpl Immunol. 2022 Oct;74:101655. doi: 10.1016/j.trim.2022.101655. Epub 2022 Jun 28.
Human BK polyomavirus (BKPyV) can affect the machinery of the host cell to induce optimal viral replication or transform them into tumor cells. Reactivation of BKPyV happens due to immunosuppression therapies following renal transplantation which might result in BK polyomavirus nephropathy (BKPyVAN) and allograft loss. The first protein that expresses after entering into host cells and has an important role in pathogenicity is the Large T antigen (LT-Ag). In this review tries to study the molecular and cellular inter-regulatory counteractions especially between CD4 and CD8 T cells, and BKPyV LT-Ag may have role in nephropathy after renal transplantation.
人 BK 多瘤病毒（BKPyV）可以影响宿主细胞的机制，诱导最佳的病毒复制或将其转化为肿瘤细胞。BKPyV 的复活是由于肾移植后免疫抑制治疗引起的，这可能导致 BK 多瘤病毒肾病（BKPyVAN）和移植物丢失。进入宿主细胞后表达的第一个具有重要致病性的蛋白是大 T 抗原（LT-Ag）。在本综述中，试图研究分子和细胞的相互调节拮抗作用，特别是 CD4 和 CD8 T 细胞之间的相互作用，以及 BKPyV LT-Ag 在肾移植后肾病中的可能作用。
Zotero 插件