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电子烟和可燃烟草戒除:基于美国一项电子烟戒烟随机对照试验的二次分析。

E-cigarette and combusted tobacco abstinence among young adults: Secondary analyses from a U.S.-based randomized controlled trial of vaping cessation.

机构信息

Innovations Center, Truth Initiative, Washington, DC, USA; Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Oncology, Georgetown University Medical Center/Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Washington, DC, USA.

Innovations Center, Truth Initiative, Washington, DC, USA.

出版信息

Prev Med. 2022 Dec;165(Pt B):107119. doi: 10.1016/j.ypmed.2022.107119. Epub 2022 Jun 28.

Abstract

OBJECTIVE

To examine patterns of abstinence from e-cigarettes, combusted tobacco products (CTPs), both, or neither among young adults enrolled in a U.S.-based randomized trial of a text message vaping cessation intervention.

METHODS

At baseline, 1829 young adult e-cigarette users were categorized as Exclusive E-cigarette Users (no past 30-day CTP use; n = 1036, 56.6%) or Dual Users (past 30-day CTP use; n = 793, 43.4%). Four groups were defined at 7-months: 1) Dual Abstinent, 2) Exclusive Vaping, 3) Exclusive CTP Use, and 4) Dual Users. The proportion of participants who were Dual Abstinent was the outcome of interest.

RESULTS

At follow-up, 22.1% (95% CI: 20.3, 24.1) of participants were Dual Abstinent, 44.8% (95% CI: 42.5, 47.1) reported Exclusive Vaping, 6.3% (95% CI: 5.2, 7.5) reported Exclusive CTP Use, and 26.8% (95% CI: 24.8, 28.9) were Dual Users. A higher proportion of participants randomized to Intervention were Dual Abstinent (25.9%, 95% CI 23.1, 28.9) compared to Control (18.5%, 95% CI 16.0, 21.1; p = .0002). Analyses of treatment effects on dual abstinence by baseline tobacco product use favored Intervention over Control among both Exclusive E-cigarette Users (p = .019) and Dual Users (p = .0014).

CONCLUSION

A text message vaping cessation intervention was effective in promoting dual abstinence from e-cigarettes and CTPs among young adults. The advantage of treatment over control was equivalent for Exclusive E-cigarette Users and Dual Users. Rates of dual abstinence were higher among exclusive vapers than dual users, signaling the need for more research to optimize cessation programs for poly-tobacco users.

摘要

目的

在美国一项基于短信的电子烟戒烟干预随机试验中,研究参与者中电子烟和可燃烟草制品(CTP)的戒烟模式,以及同时使用这两种产品或既不使用这两种产品的模式。

方法

在基线时,1829 名年轻成年电子烟使用者被分为以下两类:仅使用电子烟的使用者(过去 30 天未使用 CTP;n=1036,56.6%)或双重使用者(过去 30 天使用过 CTP;n=793,43.4%)。在 7 个月时,将参与者分为以下四类:1)双重使用者戒烟,2)仅使用电子烟,3)仅使用 CTP,4)双重使用者。感兴趣的结果是双重使用者戒烟的比例。

结果

随访时,22.1%(95%置信区间:20.3,24.1)的参与者是双重使用者戒烟,44.8%(95%置信区间:42.5,47.1)的参与者报告仅使用电子烟,6.3%(95%置信区间:5.2,7.5)的参与者报告仅使用 CTP,26.8%(95%置信区间:24.8,28.9)的参与者是双重使用者。与对照组(18.5%,95%置信区间 16.0,21.1;p=0.0002)相比,随机分配到干预组的参与者中双重使用者戒烟的比例更高(25.9%,95%置信区间 23.1,28.9)。基于基线烟草制品使用情况,对双重使用者戒烟的治疗效果分析表明,干预组优于对照组,无论是对仅使用电子烟的使用者(p=0.019)还是双重使用者(p=0.0014)。

结论

短信戒烟干预措施在促进年轻成年人同时戒烟电子烟和 CTP 方面是有效的。与对照组相比,干预组对仅使用电子烟的使用者和双重使用者的治疗效果均相当。与双重使用者相比,仅使用电子烟的使用者的双重使用者戒烟率更高,这表明需要进一步研究,以优化针对多烟草使用者的戒烟方案。

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