Carlsson L, Eriksson E, Seeman H, Jansson J O
Acta Physiol Scand. 1987 Mar;129(3):393-9. doi: 10.1111/j.1748-1716.1987.tb08083.x.
The effect of oestradiol treatment on the secretion of growth hormone (GH) was investigated in normal unrestrained male rats with chronic i.v. cannulae and in hypophysectomized male rats with autotransplanted pituitaries. The effect of gonadectomy of normal rats on the plasma GH secretory pattern was also evaluated. Baseline plasma GH levels were elevated following estradiol treatment of normal male rats (1.5 mg kg-1 per 15 days). Gonadectomy of male rats also resulted in increased baseline GH levels, although the effect was less apparent than after oestradiol administration. The pulse height was not influenced by gonadectomy or oestradiol administration. In male rats with the pituitary autotransplanted to the kidney capsule, oestradiol caused a dose-dependent increase in plasma GH levels, while there was no such effect of testosterone. These results suggest that the stimulatory influence of oestradiol on baseline GH levels is, at least partly, due to a direct effect on the pituitary. Plasma prolactin levels were elevated in rats with pituitary transplants receiving oestradiol. It is concluded that oestrogen administration to normal male rats increases baseline plasma GH levels, possibly by an effect exerted directly at the pituitary level.
采用慢性静脉插管法，对正常未受限制的雄性大鼠以及垂体自体移植的去垂体雄性大鼠，研究了雌二醇治疗对生长激素（GH）分泌的影响。同时也评估了正常大鼠去势对血浆GH分泌模式的影响。对正常雄性大鼠给予雌二醇治疗（每15天1.5mg/kg）后，基线血浆GH水平升高。雄性大鼠去势也导致基线GH水平升高，尽管其作用不如给予雌二醇后明显。脉冲高度不受去势或给予雌二醇的影响。在垂体自体移植到肾包膜的雄性大鼠中，雌二醇导致血浆GH水平呈剂量依赖性升高，而睾酮则无此作用。这些结果表明，雌二醇对基线GH水平的刺激作用至少部分是由于对垂体的直接作用。接受雌二醇的垂体移植大鼠血浆催乳素水平升高。得出的结论是，对正常雄性大鼠给予雌激素会增加基线血浆GH水平，可能是通过直接作用于垂体水平实现的。
