Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences, Tehran, Iran.
BMC Endocr Disord. 2022 Jul 1;22(1):169. doi: 10.1186/s12902-022-01084-6.
This study aimed to investigate the association between circulating levels of vitamin D binding protein (VDBP) and its genotypes and diabetic retinopathy risk.
This case-control study recruited 154 patients with type 2 diabetes mellitus; 62 with diabetic retinopathy (DR) and 92 without DR and diabetic nephropathy (DN). Circulating levels of 25-hydroxyvitamin D3 and VDBP levels were measured in the patients. The genotype and phenotype of VDBP were evaluated based on two common VDBP variations; rs7041 and rs4588.
Serum levels of VDBP were significantly lower in patients with DR than in patients without DR and/or DN (Ln-VDBP (μg/ml): 6.14 ± 0.92 vs. 6.73 ± 1.45, p = 0.001) even after adjustment for age, sex, body mass index, disease duration, estimated glomerular filtration rate (eGFR), HbA1C, insulin therapy profile, and serum levels of 25(OH)D. The distribution of VDBP phenotypes and genotypes in the two studied groups were nearly the same, and the distribution was similar to that of the general population.
In this study, we found the association between lower circulating levels of VDBP and risk of DR. However, the precise mechanism linking these two remains unknown. Further and more in-depth research is needed to find out the underlying causes of the relationship.
本研究旨在探讨循环维生素 D 结合蛋白（VDBP）水平及其基因型与糖尿病视网膜病变（DR）风险之间的关系。
本病例对照研究纳入了 154 例 2 型糖尿病患者；其中 62 例患有 DR，92 例无 DR 和糖尿病肾病（DN）。检测患者循环 25-羟维生素 D3 和 VDBP 水平。根据两种常见的 VDBP 变异（rs7041 和 rs4588）评估 VDBP 的基因型和表型。
与无 DR 和/或 DN 的患者相比，DR 患者的血清 VDBP 水平显著降低（Ln-VDBP（μg/ml）：6.14±0.92 vs. 6.73±1.45，p=0.001），即使在校正年龄、性别、体重指数、病程、估算肾小球滤过率（eGFR）、HbA1C、胰岛素治疗方案和 25（OH）D 血清水平后也是如此。在两个研究组中，VDBP 表型和基因型的分布几乎相同，且分布与一般人群相似。
在本研究中，我们发现循环 VDBP 水平较低与 DR 风险之间存在关联。然而，这两者之间的精确机制尚不清楚。需要进一步和更深入的研究来找出两者之间关系的根本原因。
