Department of Internal Medicine and Health Services, Semnan University of Medical Sciences, Semnan, Iran.
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2022 Aug;236:153982. doi: 10.1016/j.prp.2022.153982. Epub 2022 Jun 15.
Pancreatic duct adenocarcinoma, commonly known as pancreatic cancer (PC), is a cancer-related cause of death due to delayed diagnosis, metastasis, and drug resistance. Patients with PC suffer from incorrect responses to chemotherapy due to inherent and acquired chemical resistance. Numerous studies have shown the mechanism of the effect of chemoresistance on PC, such as genetic and epigenetic changes or the elucidation of signaling pathways. In this regard, microRNAs (miRNAs) have been identified as essential modulators of gene expression in various cellular functions, including chemoresistance. Thus, identifying the underlying link between microRNAs and PC chemoresistance helps determine the exact pathogenesis of PC. This study aims to classify miRNAs and signaling pathways related to PC chemoresistance, suggesting new therapeutic approaches to overcome PC chemoresistance.
胰腺导管腺癌，通常被称为胰腺癌（PC），是一种癌症相关的死亡原因，这是由于诊断延迟、转移和耐药性导致的。由于固有和获得性的化学抗性，PC 患者对化疗的反应不正确。许多研究表明了化学抗性对 PC 的作用机制，例如遗传和表观遗传变化或信号通路的阐明。在这方面，microRNAs（miRNAs）已被确定为各种细胞功能中基因表达的重要调节剂，包括化学抗性。因此，确定 miRNA 与 PC 化学抗性之间的潜在联系有助于确定 PC 的精确发病机制。本研究旨在对与 PC 化学抗性相关的 miRNAs 和信号通路进行分类，提出克服 PC 化学抗性的新治疗方法。
