运动对冠状动脉疾病患者心室舒张期时间的影响。

Effect of exercise on ventricular diastolic time in coronary artery disease.

作者信息

Sugiura T, Iwasaka T, Takahashi N, Matsutani M, Takayama Y, Inada M, Spodick D H

出版信息

Am J Cardiol. 1987 May 1;59(12):1089-92. doi: 10.1016/0002-9149(87)90854-x.

Abstract

To evaluate diastolic time during uninterrupted upright exercise, 28 normal volunteers (group 1) and 12 men with coronary artery disease (group 2) were studied by ear densitography. Electromechanical systole-heart rate and diastolic time-heart rate regression equations during upright exercise were obtained from group 1. Electromechanical systole-heart rate had an inverse linear relation (electromechanical systole = 480 - 1.4 heart rate) and diastolic time-heart rate had an inverse nonlinear relation (diastolic time = 1206e-0.02 heart rate). Although there were no significant differences in electromechanical systole and diastolic time at 1 minute of exercise between patients with and without CAD, at peak exercise prolongation of electromechanical systole and consequent shortening of diastolic time in patients with CAD were observed. This disproportionate shortening of diastole with lengthening of systole at peak exercise tends to decrease myocardial perfusion and, hence, oxygen supply, while increasing myocardial oxygen demand, contributing to aggravation of ischemia in patients with CAD.

摘要

为了评估持续直立运动期间的舒张期时间，通过耳部密度描记法对28名正常志愿者（第1组）和12名冠心病男性患者（第2组）进行了研究。从第1组获得了直立运动期间的机电收缩期-心率和舒张期时间-心率回归方程。机电收缩期-心率呈负线性关系（机电收缩期 = 480 - 1.4×心率），舒张期时间-心率呈负非线性关系（舒张期时间 = 1206e-0.02×心率）。尽管冠心病患者和非冠心病患者在运动1分钟时的机电收缩期和舒张期时间没有显著差异，但在运动峰值时，观察到冠心病患者的机电收缩期延长，随之舒张期时间缩短。在运动峰值时，随着收缩期延长舒张期不成比例地缩短，这往往会减少心肌灌注，从而减少氧气供应，同时增加心肌需氧量，导致冠心病患者的缺血加重。