Sauerbier I
Am J Anat. 1987 Feb;178(2):170-4. doi: 10.1002/aja.1001780208.
This study evaluates the ethanol toxicity for fetal development at different circadian stages. Pregnant mice were given a single intraperitoneal ethanol injection on day 7, 8, or 10 of gestation at one of four circadian stages (0700, 1300, 1900, or 0100 hr). The dams were killed on the day before term (day 18). Prenatal exposure to ethanol resulted in an increased number of resorptions, reduced fetal body weight, and produced an increased incidence of external alterations. The severity of damage was related to the dose, the period of gestation, and particularly to the circadian stage at the time of treatment. Ethanol had the greatest effect on the embryo of a mouse when administered at the mid-dark span. Consequently exposure to a single dose of ethanol at one time or another along the 24-hr time scale during organogenesis has important implications for the substantially increased risk.
本研究评估了在不同昼夜节律阶段乙醇对胎儿发育的毒性。在妊娠第7、8或10天的四个昼夜节律阶段（07:00、13:00、19:00或01:00时）之一，给怀孕小鼠腹腔内单次注射乙醇。在预产期前一天（第18天）处死母鼠。产前暴露于乙醇导致吸收胎数量增加、胎儿体重减轻，并使外部畸形的发生率增加。损伤的严重程度与剂量、妊娠期以及特别是治疗时的昼夜节律阶段有关。在黑暗中期给予乙醇时，乙醇对小鼠胚胎的影响最大。因此，在器官发生期间的24小时时间范围内的某个时间点单次暴露于乙醇会对大幅增加的风险产生重要影响。
