Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan.
Jpn J Radiol. 2022 Nov;40(11):1121-1137. doi: 10.1007/s11604-022-01306-w. Epub 2022 Jul 4.
Numerous studies have clarified the usefulness of F-fluorodeoxyglucose (FDG)-PET/CT (positron emission tomography) for diagnosing the cause of fever of unknown origin (FUO). Various types of disease can cause FUO, but the cause remains unknown in a certain proportion of FUO, even when the advanced diagnostic methodologies are used. FDG-PET/CT is regarded as a second-line modality in the diagnostic process of FUO, and its potential to identify the cause of FUO will be maximized when the appropriate clinical considerations are understood. Accordingly, this review presents basic knowledge regarding FUO, and reports the current status of FDG-PET/CT applied to diagnosing the cause of FUO, including diagnostic performance, test protocols, possible factors influencing the diagnostic result, outcomes, and cost-effectiveness. This knowledge will enable effective future use of FDG-PET/CT to improve outcomes in patients with FUO.
大量研究已经阐明了 F-氟代脱氧葡萄糖（FDG）-正电子发射断层扫描/计算机断层扫描（PET/CT）在诊断不明原因发热（FUO）病因中的作用。各种类型的疾病都可能导致 FUO，但即使使用先进的诊断方法，FUO 中仍有一定比例的病因不明。FDG-PET/CT 被认为是 FUO 诊断过程中的二线方法，当了解了适当的临床考虑因素后，它可以最大程度地确定 FUO 的病因。因此，本综述介绍了有关 FUO 的基础知识，并报告了 FDG-PET/CT 应用于诊断 FUO 病因的现状，包括诊断性能、检测方案、可能影响诊断结果的因素、结果和成本效益。这些知识将有助于未来有效使用 FDG-PET/CT 来改善 FUO 患者的预后。
