Kiyak Ata, Elibol Serra, Barutcu Ozlem, Saruc Murat, Tozun Nurdan
Acibadem University School of Medicine, Istanbul, Turkey.
Department of Radiology, Acibadem University School of Medicine; Istanbul, Turkey.
Hepatol Forum. 2021 Jan 8;2(1):26-30. doi: 10.14744/hf.2020.2020.0031. eCollection 2021 Jan.
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. The aims of the current study are to determine the relationship between NAFLD in non-obese individuals and weight gain during adulthood and develop a new index for the identification of NAFLD risk.
For this cross-sectional study, 362 patients who underwent abdominal ultrasonography (USG) in our clinic were included. Seventy-eight individuals were obese (>30 kg/m). A history of weight gain during adulthood and systemic metabolic diseases was collected at the time of the study. A new index termed "Subtracted Adulthood Mass Index" (SAMI) was created to estimate the risk of NAFLD development for non-obese people. SAMI is the ratio of the difference between the individual's current weight and his/her weight at 20 years old to his/her height squared (kg/m).
When the SAMI cut-off was set at 3 kg/m, the sensitivity for predicting NAFLD risk was 85.2%, the specificity was 66.9%, the PPV was 79.1%, and the NPV was 75.4%.
In this innovational study, a new index named SAMI was developed to identify non-obese people who are at risk of developing NAFLD. The SAMI is easy to calculate and appropriate for clinical use.
非酒精性脂肪性肝病（NAFLD）是一种常见的慢性肝病。本研究的目的是确定非肥胖个体中NAFLD与成年期体重增加之间的关系，并开发一种用于识别NAFLD风险的新指标。
在这项横断面研究中，纳入了362例在我院接受腹部超声检查（USG）的患者。78例为肥胖者（>30kg/m）。在研究时收集成年期体重增加史和全身代谢疾病史。创建了一个名为“减去成年体重指数”（SAMI）的新指标，以评估非肥胖人群发生NAFLD的风险。SAMI是个体当前体重与20岁时体重之差与身高平方的比值（kg/m）。
当SAMI临界值设定为3kg/m时，预测NAFLD风险的敏感性为85.2%，特异性为66.9%，阳性预测值为79.1%，阴性预测值为75.4%。
在这项创新性研究中，开发了一种名为SAMI的新指标，以识别有发生NAFLD风险的非肥胖人群。SAMI易于计算，适用于临床应用。
