Cremer Christopher, Patureau Frederic W
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
JACS Au. 2022 Jun 16;2(6):1318-1323. doi: 10.1021/jacsau.2c00193. eCollection 2022 Jun 27.
Very few elements in the periodic system can catalytically activate O, such as in the context of cross-dehydrogenative couplings. The development of O-activating catalysts is essential to enable new and sustainable reactivity concepts to emerge, because these catalysts also often feature specific activating interactions with the target substrates. In this context, the unprecedented Te(II)/Te(III) catalyzed dehydrogenative C3-C2 dimerization of indoles is described herein. The fact that O can be directly utilized as a terminal oxidant in this reaction, as well as the absence of any background reactivity without the redox-active Te catalyst, constitute very important milestones for the fields of cross-dehydrogenative couplings and tellurium catalysis.
在元素周期系中，能够催化活化氧的元素极少，比如在交叉脱氢偶联反应中。开发氧活化催化剂对于催生新的可持续反应概念至关重要，因为这些催化剂通常还与目标底物具有特定的活化相互作用。在此背景下，本文描述了前所未有的碲（II）/碲（III）催化吲哚的脱氢C3-C2二聚反应。在该反应中氧可直接用作终端氧化剂，以及在没有氧化还原活性碲催化剂时不存在任何背景反应性，这两个事实对于交叉脱氢偶联和碲催化领域而言都是非常重要的里程碑。
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